Look to the root of the overgrowth to understand PROS

PIK3CA-Related Overgrowth Spectrum (PROS) is a broad-ranging spectrum of overgrowth disorders that share a common link—PIK3CA mutations.1

Find the latest diagnostic criteria for PROS disorders

Watch a video about the root cause of PROS disorders


  1. Keppler-Noreuil KM, Rios JJ, Parker VER, et al. PIK3CA-related overgrowth spectrum (PROS): diagnostic and testing eligibility criteria, differential diagnosis, and evaluation. Am J Med Genet A. 2015;167A(2):287-295.